1 1 2 Autophagy during proliferation and encystation in the protozoan parasite
نویسندگان
چکیده
1 2 Autophagy during proliferation and encystation in the protozoan parasite Entamoeba 3 invadens 4 Karina Picazarri, Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki* 5 Department of Parasitology, Gunma University Graduate School of Medicine, Maebashi, 6 Gunma 371-851, Japan 7 8 *Corresponding author: Tomoyoshi Nozaki Mailing address: Department of Parasitology, 9 Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 10 371-8511, Japan. Phone: 81 27 220 8020. Fax: 81 27 220 8025. E-mail: [email protected] u.ac.jp. 12 13 Abbreviations: Eh, Entamoeba histolytica; Ei, Entamoeba invadens; Atg8, Autophagy-related 14 gene 8; PE, phosphatidylethanolamine; PAS, pre-autophagosomal structure. 15 16 The nucleotide and protein sequences reported in this paper have been submitted to DDBJ 17 with accession numbers AB326955 (EiAtg8) and AB326956 (EiAtg3). 18 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10.1128/IAI.00636-07 IAI Accepts, published online ahead of print on 8 October 2007
منابع مشابه
Autophagy during proliferation and encystation in the protozoan parasite Entamoeba invadens.
Autophagy is one of the three systems responsible for the degradation of cytosolic proteins and organelles. Autophagy has been implicated in the stress response to starvation, antigen cross-presentation, the defense against invading bacteria and viruses, differentiation, and development. Saccharomyces cerevisiae Atg8 and its mammalian ortholog, LC3, play an essential role in autophagy. The inte...
متن کاملAutophagy during proliferation and encystation in the protozoan parasite Entamoeba 3 invadens 4
1 2 Autophagy during proliferation and encystation in the protozoan parasite Entamoeba 3 invadens 4 Karina Picazarri, Kumiko Nakada-Tsukui, and Tomoyoshi Nozaki* 5 Department of Parasitology, Gunma University Graduate School of Medicine, Maebashi, 6 Gunma 371-851, Japan 7 8 *Corresponding author: Tomoyoshi Nozaki Mailing address: Department of Parasitology, 9 Gunma University Graduate School of...
متن کاملIdentification of Atg8 Isoform in Encysting Acanthamoeba
Autophagy-related protein 8 (Atg8) is an essential component of autophagy formation and encystment of cyst-forming parasites, and some protozoa, such as, Acanthamoeba, Entamoeba, and Dictyostelium, have been reported to possess a type of Atg8. In this study, an isoform of Atg8 was identified and characterized in Acanthamoeba castellanii (AcAtg8b). AcAtg8b protein was found to encode 132 amino a...
متن کاملAtg3-Mediated Lipidation of Atg8 Is Involved in Encystation of Acanthamoeba
Autophagy is a catabolic process involved in the degradation of a cell's own components for cell growth, development, homeostasis, and the recycling of cellular products. Autophagosome is an essential component in the protozoan parasite during differentiation and encystation. The present study identified and characterized autophagy-related protein (Atg) 3, a member of Atg8 conjugation system, i...
متن کاملIdentification of the major cysteine protease of Giardia and its role in encystation.
Giardia lamblia is a protozoan parasite and the earliest branching clade of eukaryota. The Giardia life cycle alternates between an asexually replicating vegetative form and an infectious cyst form. Encystation and excystation are crucial processes for the survival and transmission of Giardia. Cysteine proteases in Giardia have been implicated in proteolytic processing events that enable the co...
متن کامل